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Friday, May 15, 2020 | History

4 edition of Kainic Acid Tool Neurobio found in the catalog.

Kainic Acid Tool Neurobio

by Edith G. McGeer

  • 77 Want to read
  • 14 Currently reading

Published by Not Avail .
Written in English

    Subjects:
  • Neuroscience,
  • Medical / Nursing

  • The Physical Object
    FormatHardcover
    Number of Pages271
    ID Numbers
    Open LibraryOL8214749M
    ISBN 100890042799
    ISBN 109780890042793

    In: Kainic Acid as a Tool in Neurobiology, McGeer EG, Olney JW, McGeer PL (Eds), Raven Press, New York. Google Scholar Watkins JC, Davies J, Evans RH, Francis AA and Jones AW ().Cited by: In the late s and early s, the kainic acid model became a valued experimental model for focal epilepsy. 33 Kainic acid, an analog of the neuro‐excitatory amino acid glutamate, has excitatory effects. 34 It can be applied to various regions of the brain, but TL structures have a very high susceptibility. 33 It mainly produces limbic Cited by: 4.

      The putative excitatory transmitters glutamate and aspartate, as well as their excitatory analogues, can kill neurones in the central nervous system Cited by: Chemical Name: (2S,3S,4R)Carboxyisopropylpyrrolidineacetic acid CAS No: Molecular Weight: Activity: EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake (Ki = 23 μM). fold selective over EAAT1 and EAAT3 (Ki > 3 mM). Also available as part of the Excitatory Amino Acid Transporter.

    investigate the effect of kainic acid on the levels of glutathione (GSH) and nitrite in rat hippocampus. MATERIALS AND METHODS Animals and treatments Twenty adult Wistar rats, weighing g, were used in the present study. All animals were maintained on a 12 h light: dark cycle and given continuous access to food and water.   Kainic Acid and Related Compounds as a Pharmacological Tool Actions of kainic acid and related analogues on Hirudo, Helix and LimuJus central neurones A comparison between the glutamate response and the excitatory junctional potential in the presence of kainic acid at the crayfish neuromuscular junctionBook Edition: 1.


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Kainic Acid Tool Neurobio by Edith G. McGeer Download PDF EPUB FB2

Kainic Acid Tool Neurobio: Medicine & Health Science Books @ Skip to main content. Try Prime EN Hello, Sign in Account & Lists Sign in Account & Lists Returns & Orders Try Prime Cart. Books. Go Search Hello Select your address. OLNEY, John W.

KAINIC ACID AS A TOOL IN NEUROBIOLOGY. NY: Raven Press. 8vo. red cloth in dust jacket. First Edition. Signed presentation. Additional Physical Format: Online version: Kainic acid as a tool in neurobiology.

New York: Raven Press, © (OCoLC) Document Type: Book. Kainic acid as a tool in neurobiology Published by Raven Press in New York. Written in EnglishPages: A highly practical stereoselective total synthesis of (−)-kainic acid is described.

This synthesis features the stereoselective alkylation of an iodolactone intermediate that was efficiently prepared from (+)-carvone and introduction of carboxylic acid by hydrolysis of a nitrile accompanied by epimerizaion.

This synthetic route enabled us to obtain g of (−)-kainic acid. A % increase in [3H]kainic acid binding was observed in the medial frontal (Brodmann areas 9, 10 and 46) and eye-movement areas (8), but not in the other regions of schizophrenic brains.

No significant correlation between the binding and either Kainic Acid Tool Neurobio book at death, storage of the brains, duration of illness or neuroleptics-free period was by: In: Mcgeer EG, Olney JW (eds) Kainic acid as a tool in neurobiology.

Raven Press, New York, pp 95– Google Scholar Parkinson Study Group () Impact of deprenyl and tocopherol treatment on Parkinson’s disease in DATATOP subjects not requiring : M.

Gerlach, P. Riederer. (U.S.A.) (Accepted June 26th, ) Key words: dipiperidinoethane -- neurotoxicity -- kainic acid -- convulsants Kainic acid (KA) is one of the most powerful of a group of structural analogs of glutamate (Glu) and aspartate (Asp) that have both neuroexcitatory11 and neuro- toxic6,9 by: Kainic acid is an agonist at the kainate class of ionotropic glutamate receptors.

Kainic acid induces seizures and neurodegeneration, when injected in vivo. It is commonly used to induce experimental epilepsy in rodents (via the induction of a status epilepticus, SE), and to study the mechanisms of excitation-induced neuronal apoptosis.

Some neurophysiological studies suggest that the cerebellum participate in epileptic activity. Deep cerebellar nuclei are highly responsive to kainic acid. We examine epileptic activity in rats injected with kainic acid in the cerebellar nuclei.

We found that the dentate and interpositus nuclei lesions interfere with the kindling phenomena. Therefore, cerebellar lesions interfere in seizures when the thalamus and neocortex Cited by: 4. Kainic acid.

KA is a cyclic analog of L-glutamate and an agonist of ionotropic KA receptors. It was isolated and extracted in the early s, from a red algae (Digenea simplex) found in tropical and sub-tropical waters (Murakami et al., ).It was named digenic acid but this term was later changed to KA in order to avoid confusion with the other derivatives of Digenea (Nadler, ).Cited by:   Kainic acid (KA), an analog of excitotoxic glutamate, can elicit selective neuronal death in the brain of rodents, of which the pathological changes partially mimic neurodegeneration in the CNS.

Thus, KA-induced neurodegeneration in rodents has been used as a model for exploring the pathogenesis of excitotoxicity in neurodegenerative by: Abstract. Acromelic acid, one of kainoids which possess a constitutional moiety of kainic acid, has been isolated from a poisonous mushroom.

Acromelic acid proved to be one of the most potent excitatory amino acids in both vertebrates and invertebrates; superior to other kainoids in depolarizing activity on newborn rat spinal by: 4.

Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts Nur Shafika Mohd Sairazi, 1 K. Sirajudeen, 1, * Mohd Asnizam Asari, 2 Mustapha Muzaimi, 3 Swamy Mummedy, 1 and Siti Amrah Sulaiman 4Cited by: 8.

Kainic Acid Seizures and Neuronal Cell Death: Insights from Studies of Selective Lesions and Drugs Downloads; Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume ) Nadler, J.V.,Kainic acid as a tool for the study of temporal lobe epilepsy, Life Sqi.

Google Scholar. Cited by: PDF | The impact of a scientific article is proportional to the citations it has received. In this study, we set out to identify the most cited works in | Find, read and cite all the research. Kainic acid is a powerful neurotoxin which kills neurons by means of overexcitation.

It is isolated from a seaweed known for its potency at killing intestinal worms. The word ‘kainic’ is derived from the Japanese kaininso which means the ‘ghost of the sea’. Kainic acid, or kainate, is an acid that naturally occurs in some seaweed. Kainic acid is a potent neuroexcitatory amino acid agonist that acts by activating receptors for glutamate, the principal excitatory neurotransmitter in the central nervous system.

Glutamate is produced by the cell's metabolic processes Beilstein Reference: Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptortype IB protects neurons against kainic acid-induced neurodegeneration. 5/5(1). Kainic acid is the prototypic, selective kainate receptor (KAR) agonist.

Analog of L-Glutamate. Kainic acid is a potent excitant and neurotoxin (shows ~fold more neurotoxic potency than L-Glutamate). It induces various changes in vivo including recurrent seizures, behavioural changes, oxidative stress, glial activation and selective neuronal 5/5(5).

Watkins and Evans () Excitatory amino acid transmitters. l. 21 PMID: Watkins () Excitatory amino acids. Kainic acid as a Tool 5/5(1).Kainic acid (KA) is an agonist for a subtype of ionotropic glutamate receptor, and administration of KA has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions of CA1 and CA3, and in the hilus of dentate gyrus (DG).Cited by:   1.

Introduction. Kainic acid (KA) is a potent agonist to the α-aminohydroxymethylisoxazolepropionic acid (AMPA)/kainate administration of KA commonly induces epileptic seizures and excitotoxic cell death in the hippocampus, similar to that observed in temporal lobe epilepsy patients [1, 2].Therefore it has been widely used for seizure animal studies as a trigger to Cited by: 8.